Tetraarsenic tetrasulfide triggers ROS-induced apoptosis and ferroptosis in B-cell acute lymphoblastic leukaemia by targeting HK2

Purpose: Acute lymphoblastic leukemia (ALL) is the most common type of cancer diagnosed in children.Despite cure rates of higher than 85 %, refractory or relapsed ALL still exhibits a bleak prognosis indicative of the dearth of treatment modalities specific for relapsed or refractory ALL.Prior research has implicated metabolic alterations in leukem

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LGBT Climate Inventory in Corporations for Straight People?

Open societies are eager to accommodate sexual and gender diversity at work.The Lesbian, Gay, Bisexuals and Trans Climate Inventory (LGBTCI) is an instrument measuring organizational climate towards sexual and gender diversity, relying on the opinion of LGTB people.We argue that non-LGTB employees also perceive a climate towards sexual and gender d

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Revitalising South African City Centres Through ICT

The majority of South African city centres are in a state of degeneration and need revitalising.The factors that contributed to the degeneration and how the integration of information and communications technology (ICT) can be used to revitalise them were examined in three South African city centres.The research was grounded in place theory.A surve

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